A recent study reveals that patients who come off blockbuster weight-loss injections like Wegovy and Mounjaro can put back on shed pounds much more quickly than those who halt traditional lifestyle plans.
Findings released in a major medical journal shows that while overweight people frequently drop substantial amounts of their total mass while on the medication, the mass returns at an estimated rate of nearly a kilo each month upon discontinuation.
"People buying such treatments must be informed of the danger of fast weight regain when the treatment ends," cautioned expert Dr. Susan Jebb.
That rate of recovery means a reversion to starting mass within about 18 months.
Analyzing Therapies
The analysis, which looked at 37 of trials involving thousands of patients, contrasted the outcomes of the injectable medications with other pills.
Scientists point out that individuals who lose weight through diet and exercise generally have a less rapid weight regain—perhaps 0.1 kg a month—after stopping.
The Reason for the Fast Rebound
Experts suggest the mechanism of the drugs is key to understanding the accelerated regain.
These medications mimic a natural hormone called glucagon-like peptide-1, which controls appetite.
"Long-term administration of the hormone levels far above than normal could lead to the body to generate a reduced amount of its endogenous GLP-1, and may also lessen responsiveness to its effects," noted Dr. Adam Collins, a nutrition researcher.
"Stopping of this medication leads to hunger is unsuppressed, making overeating far more likely."
A Chronic Disease?
Health authorities recommend the injections for individuals with obesity-related health risks, accompanied by recommended diet and exercise modifications.
Many experts argue that, considering the likelihood of relapse, the therapy should be considered life-long.
This view is supported by pharmaceutical companies, who note that the findings "emphasize the chronic character of obesity," similar to managing conditions like diabetes.
Patient Experiences
People who have come off the medication explain a sudden resurgence of appetite.
"I experienced something flipping and I was suddenly ravenous," described an individual.
This challenge is worsened if individuals have not adopted lasting dietary or behavioural modifications during therapy.
Widespread Adoption
Figures show that a significant number of people in the UK have tried weight-loss jabs in the last 12 months, with demand being substantial.
- Adoption is higher among women compared to males.
- The 40s and 50s age group shows the highest level of interest.
- A large proportion access the drugs through private prescriptions rather than public health services.
Ultimately, experts emphasize that while these medications are effective tools for shedding pounds, they are not a magic solution and maintained weight loss relies on combined lifestyle support.
